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CGP71683 hydrochloride
CAS No. 192322-50-2
CGP71683 hydrochloride( CGP71683A )
Catalog No. M20256 CAS No. 192322-50-2
CGP71683 is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 113 | In Stock |
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| 5MG | 102 | In Stock |
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| 10MG | 154 | In Stock |
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| 25MG | 256 | In Stock |
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| 50MG | 361 | In Stock |
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| 100MG | 528 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCGP71683 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCGP71683 is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.
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DescriptionCGP71683 is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.
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In VitroCGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.
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In VivoCGP71683 (15 nmol/rat, icv, twice daily) shows anorexigenic effect, reducing food intake and bady weight of fed rats. CGP71683 causes 3-times higher serum total T4 and 37% increase in free T4 in the fasted rats than in the fasted controls rats.
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SynonymsCGP71683A
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PathwayGPCR/G Protein
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TargetNeuropeptide Y Receptor
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RecptorY5 receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number192322-50-2
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Formula Weight512.07
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Molecular FormulaC26H30ClN5O2S
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Purity>98% (HPLC)
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SolubilityDMSO: 120 mg/mL (234.34 mM);Water: 10 mg/mL (19.53 mM)
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SMILESCl.Nc1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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[Leu31,Pro34]-Neurop...
High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.
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M40
Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
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Galanin Receptor Lig...
The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. The radiolabelled M35 and performed equilibrium binding studies with [125I] M35 on the rat pancreatic beta-cell line Rin m 5F.
