CGP71683 hydrochloride

CAS No. 192322-50-2

CGP71683 hydrochloride( CGP71683A )

Catalog No. M20256 CAS No. 192322-50-2

CGP71683 is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 113 In Stock
5MG 102 In Stock
10MG 154 In Stock
25MG 256 In Stock
50MG 361 In Stock
100MG 528 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    CGP71683 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    CGP71683 is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.
  • Description
    CGP71683 is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.
  • In Vitro
    CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.
  • In Vivo
    CGP71683 (15 nmol/rat, icv, twice daily) shows anorexigenic effect, reducing food intake and bady weight of fed rats. CGP71683 causes 3-times higher serum total T4 and 37% increase in free T4 in the fasted rats than in the fasted controls rats.
  • Synonyms
    CGP71683A
  • Pathway
    GPCR/G Protein
  • Target
    Neuropeptide Y Receptor
  • Recptor
    Y5 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    192322-50-2
  • Formula Weight
    512.07
  • Molecular Formula
    C26H30ClN5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 120 mg/mL (234.34 mM);Water: 10 mg/mL (19.53 mM)
  • SMILES
    Cl.Nc1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lecklin A et al. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br J Pharmacol. 2002 Apr;135(8):2029-37.
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