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LOC14
CAS No. 877963-94-5
LOC14( —— )
Catalog No. M20192 CAS No. 877963-94-5
LOC14 to be the most potent PDI inhibitor reported to date( EC50 : 500 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 41 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 162 | In Stock |
|
| 50MG | 288 | In Stock |
|
| 100MG | 505 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLOC14
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NoteResearch use only, not for human use.
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Brief DescriptionLOC14 to be the most potent PDI inhibitor reported to date( EC50 : 500 nM).
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DescriptionLOC14 to be the most potent PDI inhibitor reported to date( EC50 : 500 nM).
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In VitroCell Viability Assay Cell Line:MTEC cells Concentration:0.01 μM; 0.1 μM; 0.5 μM; 1 μM; 5 μM; 10 μM; 100 μM Incubation Time:24 hours Result:Inhibited recombinant (r)PDIA3 activity.
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In VivoAnimal Model:Male N171–82Q HD mice Dosage:20 mg/kg Administration:Orally administered by gavage; 20 mg/kg; once daily; 12-28 weeks Result:Improved motor function in HD mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPDI
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Research Area——
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Indication——
Chemical Information
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CAS Number877963-94-5
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Formula Weight317.4
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Molecular FormulaC16H19N3O2S
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Purity>98% (HPLC)
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SolubilityDMSO:25 mg/mL?(78.76 mM)
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SMILESO=C(C1CC1)N1CCN(Cn2sc3ccccc3c2=O)CC1
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Chemical Name2-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-12-benzisothiazol-3(2H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kaplan A et al. Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2245-52.
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