VK3-OCH3

Research use only, not for human use.

2-[(2-Methoxy)ethylthio]-3-methyl-14-na is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue.

2-[(2-Methoxy)ethylthio]-3-methyl-14-na is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue.

VK3-OCH3 (compound 5) shows cytotoxicity with IC50s of 2.43, 1.55, 10.69, 3.45, 26.24, 87.11 μM for IMR-32, LA-N-1, NB-39, SK-N-SH, HUVEC, HDF cells, respectively.VK3-OCH3 (1, 3, 10 μM) induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells.VK3-OCH3 (0-48 h) increases the expression of HO-1 in 8~24 h, and Caveolin-1 in 48 h in IMR-32 and LA-N-1 cells.VK3-OCH3 (0-48 h) increases the expression of phospho-p38-MAPK and decreases the expression of p21 and clusterin.

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2-[(2-Methoxy)ethylthio]-3-methyl-14-na

Others

Other Targets

Others

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255906-59-3

262.32

C14H14O3S

>98% (HPLC)

DMSO:25mg/mL(95.3 mM)

COCCSC1=C(C)C(=O)c2ccccc2C1=O

2-[(2-Methoxyethyl)thio]-3-methyl-14-naphthalenedione

(-20℃)

With Ice Pack

≥ 2 years