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Loreclezole
CAS No. 117857-45-1
Loreclezole( —— )
Catalog No. M20110 CAS No. 117857-45-1
Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 32 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 98 | In Stock |
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| 50MG | 178 | In Stock |
|
| 100MG | 265 | In Stock |
|
| 200MG | 377 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLoreclezole
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NoteResearch use only, not for human use.
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Brief DescriptionLoreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
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DescriptionLoreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
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In Vitro——
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In VivoLoreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test. Animal Model:Adult male Lister Hooded rats.Dosage:10, 25, 50 or 75 mg/kg.Administration:IP, 60 min before measurement of seizure threshold.Result:Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGABAA
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Research Area——
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Indication——
Chemical Information
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CAS Number117857-45-1
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Formula Weight274.53
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Molecular FormulaC10H6Cl3N3
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Purity>98% (HPLC)
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SolubilityDMSO: 90 mg/mL (327.83 mM)
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SMILESCl\C(=C/n1cncn1)c1ccc(Cl)cc1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Donnelly JL et al. Loreclezole enhances apparent desensitization of recombinant GABAA receptor currents. Neuropharmacology. 1996;35(9-10):1233-41.
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