IWP-O1( —— )

Catalog No. M20089 CAS No. 2074607-48-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

IWP-O1
Note

Research use only, not for human use.
Brief Description

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM) effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
Description

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM) effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
In Vitro

IWP-O1 (17) suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM, 2.5 times more active than the investigational drug LGK974.
In Vivo

——
Synonyms

——
Pathway

Wnt/Notch/Hedgehog
Target

Porcupine
Recptor

Porcn
Research Area

——
Indication

——

CAS Number

2074607-48-8
Formula Weight

432.48
Molecular Formula

C26H20N6O
Purity

>98% (HPLC)
Solubility

DMSO: 100 mg/mL
SMILES

O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1ccccc1
Chemical Name

5-Phenyl-N-(5-phenylpyridin-2-yl)-4-(pyridin-4-yl)-1H-123-triazol-1-acetamide

1.You L et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895.

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