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TGN020
CAS No. 51987-99-6
TGN020( —— )
Catalog No. M19928 CAS No. 51987-99-6
TGN-020 is an inhibitor of Aquaporin 4 (AQP4 IC50: 3.1 μM) the most abundant water channel in the brain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 127 | In Stock |
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| 50MG | 202 | In Stock |
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| 100MG | 321 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTGN020
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NoteResearch use only, not for human use.
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Brief DescriptionTGN-020 is an inhibitor of Aquaporin 4 (AQP4 IC50: 3.1 μM) the most abundant water channel in the brain.
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DescriptionTGN-020 is an inhibitor of Aquaporin 4 (AQP4 IC50: 3.1 μM) the most abundant water channel in the brain.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.(In Vivo):TGN-020 (0.02 mg/μL; two microliter intravitreal injections) can suppress retinal edema in STZ-induced diabetic rats (nine-week-old male Wistar rats) retinas.TGN-020 (100 mg/kg; ip; single dose immediately followed SCI) promotes functional recovery at days 3, 7, 14, 21, and 28, as well as reduces the degree of edema and inhibits the expression of AQP4, GFAP, PCNA at days 3 after SCI. TGN-020 inhibits the glial scar formation and upregulates GAP-43 expression in adult female Sprague-Dawley rats (180-220 g, 9-10 weeks old) with SCI.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They are for reference only.
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In VivoTGN-020 (0.02 mg/μL; two microliter intravitreal injections) can suppress retinal edema in STZ-induced diabetic rats (nine-week-old male Wistar rats) retinas.TGN-020 (100?mg/kg; ip; single dose immediately followed SCI) promotes functional recovery at days 3, 7, 14, 21, and 28, as well as reduces the degree of edema and inhibits the expression of AQP4, GFAP, PCNA at days 3 after SCI. TGN-020 inhibits the glial scar formation and upregulates GAP-43 expression in adult female Sprague-Dawley rats (180-220?g, 9-10?weeks old) with SCI.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorAQP4
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Research Area——
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Indication——
Chemical Information
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CAS Number51987-99-6
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Formula Weight206.22
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Molecular FormulaC8H6N4OS
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Purity>98% (HPLC)
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SolubilityDMSO: 8 mg/mL
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SMILESO=C(Nc1nncs1)c1cccnc1
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Chemical NameN-134-Thiadiazol-2-yl-3-pyridinecarboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Ginsenoside Rh3
Ginsenoside Rh3 is a natural product extracted from Ginseng C. A. Mey.Ginsenoside Rh3 has antifungal and antioxidant activities and induces Nrf2 activation in human retinal cells.
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Aloenin aglycone
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα.
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BI-0474
BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G12C mutation, and shows significant anti-tumor activity in a non-small cell lung cancer xenograft model.
