Fupentixol Dihydrochloride

Research use only, not for human use.

Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.

Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.(In Vitro):Flupentixol (2.5-40 μM; 72 h) treatment inhibits the viability of lung cancer cells in a dose-dependent manner.Flupentixol (2.5-40 μM; 24 h) induces apoptosis in lung cancer cells.Flupentixol (2.5-15 μM; 24 h) inhibits p-AKT and Bcl-2 expression levels.(In Vivo):Flupentixol (intragastric injection; 40 mg/kg; once daily; 21 d) suppresses A549 xenografted tumor growth in nude mice.

Flupentixol (2.5-40 μM; 72 h) treatment inhibits the viability of lung cancer cells in a dose-dependent manner.Flupentixol (2.5-40 μM; 24 h) induces apoptosis in lung cancer cells.Flupentixol (2.5-15 μM; 24 h) inhibits p-AKT and Bcl-2 expression levels. Cell Viability AssayCell Line:A549, H661, SK-SEM-1, and NCAL-H520 cells Concentration:2.5, 5, 10, 20, or 40 μM Incubation Time:72 hours Result:Showed the IC50s of 5.708 μM and 6.374 μM for A549 and H661 cells, respectively.Apoptosis Analysis Cell Line:A549 and H661 cells Concentration:5, 10, 20 and 40 μM Incubation Time:24 hours Result:Increased the percentage of cells in early apoptosis compared with the negative control in both A549 and H661 (p<0.05).Induced the cleavage of PARP and caspase-3 in a dose-dependent manner.Western Blot Analysis Cell Line:A549 and H661 cells Concentration:2.5, 5, 10, and 15 μM Incubation Time:24 hours Result:Decreased AKT phosphorylation levels in a dose-dependent manner, decreased the expression levels of Bcl-2.

Flupentixol (intragastric injection; 40 mg/kg; once daily; 21 d) suppresses A549 xenografted tumor growth in nude mice. Animal Model:BALB/C nude mice injected with A549 cellsDosage:40 mg/kg Administration: Intragastric injection; 40 mg/kg; once daily; 21 days Result:Reduced tumor volumes compared to the vehicle control (p<0.05), reduced tumor weights by 64.1% (p<0.05).

Flupenthixol dihydrochloride | Flupentixol dihydrochloride | (E/Z)-Flupentixol Dihydrochloride

GPCR/G Protein

Dopamine Receptor

D1 D2

Neurological Disease

schizophrenia

2413-38-9

507.43

C23H27Cl2F3N2OS

>98% (HPLC)

DMSO: 95 mg/mL;Water: 95 mg/mL;Ethanol: 25 mg/mL

Cl.Cl.OCCN1CCN(CC\C=C2\c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1

——

(-20℃)

With Ice Pack

≥ 2 years