Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation.

573'4'-Tetramethoxyflavone one of the major polymethoxyflavones (PMFs) isolated from M. exotica possesses various bioactivities including anti-fungal anti-malarial anti-mycobacterial and anti-inflammatory activities. 573'4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling.

Tenacissoside H has antitumor activity on esophageal cancer through arresting cell cycle and regulating PI3K/Akt-NF-κB transduction cascade.