Benznidazole

Research use only, not for human use.

Benznidazole has an antiprotozoal activity by interfering with parasite protein biosynthesis influencing cytokines production and stimulating host phagocytosis.

Benznidazole has an antiprotozoal activity by interfering with parasite protein biosynthesis influencing cytokines production and stimulating host phagocytosis.(In Vivo):Benznidazole (100 mg/kg/day, p.o., 30 days) produces a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart, in mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 isolate and treated at 180 days post infection (p.i.) (i.e. chronic phase) with Benznidazole.

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Benznidazole (100 mg/kg/day, p.o., 30 days) produces a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart, inmice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 isolate and treated at 180 days post infection (p.i.) (i.e. chronic phase) with Benznidazole. Animal Model:Mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 Dosage:100 mg/kg/day Administration:Orally for 30 daysResult:Produced a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart.

Ro 71051 | Benznidazol | Ro 07-1051 | Radanil

Microbiology/Virology

Antibiotic

antiprotozoal

Inflammation/Immunology

Chagas disease

22994-85-0

260.25

C12H12N4O3

>98% (HPLC)

Methanol: 50 mg/mL;DMSO: 30 mg/mL

[O-][N+](=O)c1nccn1CC(=O)NCc1ccccc1

2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide

(-20℃)

With Ice Pack

≥ 2 years