1-Methylguanidine hydrochloride( —— )

Catalog No. M19576 CAS No. 21770-81-0

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HNMR

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Product Name

1-Methylguanidine hydrochloride
Note

Research use only, not for human use.
Brief Description

Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction.
Description

Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure however it also exhibits anti-inflammatory effects. Methylguanidine is synthesized from creatinine concomitant with the synthesis of hydrogen peroxide from endogenous substrates in peroxisomes. Recent evidence suggests that methylguanidine significantly inhibits iNOS activity and TNF- release. This means that methylguandine can attenuate the degree of inflammation and tissue damage associated with endotoxic shock.
In Vitro

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In Vivo

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Indication

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1.Silwood CJ Lynch E Claxson AW Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7.

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