diethyl hexyl phthalate( DEHP )

Catalog No. M19553 CAS No. 117-81-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

diethyl hexyl phthalate
Note

Research use only, not for human use.
Brief Description

Bis(2-ethylhexyl) Phthalate plasticizer is used to impart softness and flexibility to PVC products. Bis(2-ethylhexyl) Phthalate has been implicated in obesity and insulin resistance. It inhibits prostaglandin synthesis and adversely affects the endocrine system.
Description

Bis(2-ethylhexyl) Phthalate plasticizer is used to impart softness and flexibility to PVC products. Bis(2-ethylhexyl) Phthalate has been implicated in obesity and insulin resistance. It inhibits prostaglandin synthesis and adversely affects the endocrine system.
In Vitro

Western Blot Analysis Cell Line:Mouse GC-1 spg cells Concentration:0-160 μM Incubation Time:48 h Result:Decreased Bcl-2 level. Increased the levels of Bax, cleaved Caspase-3, and cleaved Caspase-8.Increased the levels of LC3-II, Beclin1, and Atg5, as well as the ratio of LC3-II/LC3-I.
In Vivo

Animal Model:Female C3H/N mice Dosage:0-500 mg/kg Administration:p.o., daily, 8 weeks Result:Increased the body weight and visceral fat tissue.Increased the expression of PPARα and PPARγ mRNA at the dose of 500 mg/kg.Decreased mRNA expression of PPARα transcripts/106 18S molecules at the dose of 500 mg/kg.Reduced the level of adiponectin mRNA.Increased the mRNA concentration of FABP4 at the dose of 0.05 mg/kg.
Synonyms

DEHP
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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1.Corradetti B et al. Bis-(2-ethylexhyl) phthalate impairs spermatogenesis in zebrafish (Danio rerio). Reprod Biol. 2013 Sep;13(3):195-202.

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