Cilengitide trifluoroacetate( EMD 121974 | NSC 707544 )

Catalog No. M19460 CAS No. 199807-35-7

COA

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HNMR

HPLC

MSDS

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Product Name

Cilengitide trifluoroacetate
Note

Research use only, not for human use.
Brief Description

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Description

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
In Vitro

——
In Vivo

——
Synonyms

EMD 121974 | NSC 707544
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

αvβ3 receptor |αvβ5 receptor
Research Area

Cancer
Indication

Glioblastoma; Head and neck Cancer; Lymphoma; Non-small cell lung Cancer; Prostate Cancer; Solid tumours

CAS Number

199807-35-7
Formula Weight

702.68
Molecular Formula

C29H41F3N8O9
Purity

>98% (HPLC)
Solubility

DMSO:93 mg/mL (132.4 mM);Ethanol:<1 mg/mL;Water:8 mg/mL (11.38 mM)
SMILES

OC(=O)C(F)(F)F.CC(C)[C@@H]1N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC1=O
Chemical Name

——

1.Nisato RE et al. Angiogenesis 2003 6(2) 105-119.

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