MSDC 0602( MSDC-0602 | MSDC0602 )

Catalog No. M19353 CAS No. 1133819-87-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

MSDC 0602
Note

Research use only, not for human use.
Brief Description

MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes.
Description

MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes (metabolic modulator).
In Vitro

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In Vivo

Animal Model:HTF-C diet feeding C57BL6/J mice Dosage:331 ppm MSDC-0602 potassium salt (2-5 μM MSDC-0602 in blood)Administration:oral administration for 12 weeks (after 4 weeks of HTF-C diet) or 3 weeks (16 weeks after HTF-C diet)Result:Induced weight loss, decreased concentrations of plasma ALT and AST and stellate cell activation.Animal Model:HTF-C diet feeding LS-Mpc2-/-C57BL6/J mice Dosage:331 ppm MSDC-0602 potassium salt (2-5 μM MSDC-0602 in blood) Administration:oral administration for 12 weeks (after 4 weeks of HTF-C diet)Result:Induced weight loss, suppressed stellate cell activation.
Synonyms

MSDC-0602 | MSDC0602
Pathway

Others
Target

Other Targets
Recptor

mTOR
Research Area

——
Indication

——

CAS Number

1133819-87-0
Formula Weight

371.4
Molecular Formula

C19H17NO5S
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL 336.56 mM; H2O : < 0.1 mg/mL
SMILES

COc1cccc(c1)C(=O)COc3ccc(CC2SC(=O)NC2=O)cc3
Chemical Name

5-(4-(2-(3-methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione

1.McCommis KS et al. Hepatology. 2016 Dec 27. doi: 10.1002/hep.29025.

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