Lawsone( Lawsone )

Catalog No. M19160 CAS No. 83-72-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Lawsone
Note

Research use only, not for human use.
Brief Description

Lawsone (2-hydroxy-1,4-naphthoquinone), also known as hennotannic acid, is a red-orange dye present in the leaves of the henna plant (Lawsonia inermis) as well as in the flower of water hyacinth (Eichhornia crassipes).
Description

Lawsone is a molluscacide from leaves of Lawsonia inermis L. topical sunscreening agent; powdered leaves of Lawsonia inermis(Lythraceae) used as brown hair dye.
In Vitro

Cell Proliferation Assay Cell Line:DLD-1, MRC-5 Concentration:0.5, 1, 1.5, 2 mg/mL Incubation Time:24-96 h Result:Demonstrated significant suppression at concentration 2 mg/ml on DLD-1 cells and exhibited no suppression on normal fibroblast MRC-5 cells.Western Blot Analysis Cell Line:DLD-1 Concentration:0.5, 1, 1.5, 2 mg/mL Incubation Time:48 h Result:Decreased the level of both proteins cyclin B1 and cdk1. Exhibited a dose-dependent effect on translocation of p65 of cytosol to the nucleus.
In Vivo

Animal Model:Female rat model (10-11- week-old)Dosage:62.5, 125, 250, 500, 750 μmol/kg/day Administration:p.o.Result:Increased the levels of ALT、AST、GLDH、LDH、HBDH、urea and creatinine at a dose of 500 or 750 μmol/kg/day.Animal Model:Rat model of colon cancer Dosage: 200 mg/mL Administration:p.o.Result:Reduced the tumor diameters and decreased multiplicity of these adenomas.
Synonyms

Lawsone
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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1. Munt DJ, et al. AAPS PharmSciTech. 2015 Dec;16(6):1425-33.

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