Lawsone

Research use only, not for human use.

Lawsone (2-hydroxy-1,4-naphthoquinone), also known as hennotannic acid, is a red-orange dye present in the leaves of the henna plant (Lawsonia inermis) as well as in the flower of water hyacinth (Eichhornia crassipes).

Lawsone is a molluscacide from leaves of Lawsonia inermis L. topical sunscreening agent; powdered leaves of Lawsonia inermis(Lythraceae) used as brown hair dye.

Cell Proliferation Assay Cell Line:DLD-1, MRC-5 Concentration:0.5, 1, 1.5, 2 mg/mL Incubation Time:24-96 h Result:Demonstrated significant suppression at concentration 2 mg/ml on DLD-1 cells and exhibited no suppression on normal fibroblast MRC-5 cells.Western Blot Analysis Cell Line:DLD-1 Concentration:0.5, 1, 1.5, 2 mg/mL Incubation Time:48 h Result:Decreased the level of both proteins cyclin B1 and cdk1. Exhibited a dose-dependent effect on translocation of p65 of cytosol to the nucleus.

Animal Model:Female rat model (10-11- week-old)Dosage:62.5, 125, 250, 500, 750 μmol/kg/day Administration:p.o.Result:Increased the levels of ALT、AST、GLDH、LDH、HBDH、urea and creatinine at a dose of 500 or 750 μmol/kg/day.Animal Model:Rat model of colon cancer Dosage: 200 mg/mL Administration:p.o.Result:Reduced the tumor diameters and decreased multiplicity of these adenomas.

Lawsone

Others

Other Targets

Others

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83-72-7

174.16

C10H6O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (574.22 mM)

c1ccc2c(c1)C(=O)C(=CC2=O)O

1,4-Naphthalenedione, 2-hydroxy-

(-20℃)

With Ice Pack

≥ 2 years