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Bimolane
CAS No. 74550-97-3
Bimolane( AT-1727 | AT1727 | CCRIS 7574 | Bimolane )
Catalog No. M19065 CAS No. 74550-97-3
Bimolane is a topoisomerase II inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 83 | In Stock |
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| 25MG | 198 | In Stock |
|
| 50MG | 335 | In Stock |
|
| 100MG | 458 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1042 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBimolane
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NoteResearch use only, not for human use.
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Brief DescriptionBimolane is a topoisomerase II inhibitor.
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DescriptionBimolane is a topoisomerase II inhibitor. Bimolane has been widely used in China as an anti-neoplastic agent and for the treatment of psoriasis. Bimolane is also a leukemogenic agent and is thought to exert its effects through the inhibition of topoisomerase II. The results of enzyme and DNA titration assays indicate that inhibition of topoisomerase II by bimolane occurred through interactions with DNA, similar to the mechanism seen with the epipodophyllotoxin-type inhibitors. These results provide evidence that bimolane is an inhibitor of topoisomerase II in vitro.
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In Vitro——
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In Vivo——
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SynonymsAT-1727 | AT1727 | CCRIS 7574 | Bimolane
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PathwayOthers
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TargetOther Targets
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RecptorTopo II
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Research Area——
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Indication——
Chemical Information
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CAS Number74550-97-3
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Formula Weight452.51
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Molecular FormulaC20H32N6O6
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Purity>98% (HPLC)
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Solubility——
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SMILESN1(C(=O)CN(CC1=O)CCN1CC(=O)N(C(=O)C1)CN1CCOCC1)CN1CCOCC1
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Chemical Name1-(morpholin-4-ylmethyl)-4-[2-[4-(morpholin-4-ylmethyl)-3,5-dioxopiperazin-1-yl]ethyl]piperazine-2,6-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Vuong MC, Hasegawa LS, Eastmond DA. A comparative study of the cytotoxic and genotoxic effects of ICRF-154 and bimolane, two catalytic inhibitors of topoisomerase II. Mutat Res. 2013 Jan 20;750(1-2):63-71.
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