Cart
sales@molnova.com
Atractylenolide III
CAS No. 73030-71-4
Atractylenolide III( ICodonolactone | 8β-Hydroxyasterolide )
Catalog No. M19046 CAS No. 73030-71-4
Atractylenolide III may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 53 | In Stock |
|
| 2MG | 31 | In Stock |
|
| 5MG | 48 | In Stock |
|
| 10MG | 75 | In Stock |
|
| 25MG | 123 | In Stock |
|
| 50MG | 176 | In Stock |
|
| 100MG | 263 | In Stock |
|
| 200MG | 390 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAtractylenolide III
-
NoteResearch use only, not for human use.
-
Brief DescriptionAtractylenolide III may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury.
-
DescriptionAtractylenolide III may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung carcinoma by inducing the release of cytochrome c, upregulating the expression of Bax and translocating apoptosis-inducing factor.
-
In VitroWestern Blot Analysis Cell Line:A549 Concentration:1, 10, 100 μM Incubation Time:24 h, 48 h Result:Increased active form of caspase-9, caspase-3, and the cleavage of PARP at 48 h.Increased the expression of proapoptotic protein bax, and induced AIF translocation to the nucleus at 24 h.
-
In VivoAnimal Model:70% ethanol-induced gastric ulcers in rats Dosage:5 and 10 mg/kg Administration:p.o.Result:Inhibited gastric ulcer formation and the necrotic erosion of gastric mucosa.Downregulated the MMP-2/9 expression by activating the TIMP-2 and TIMP-1 expressions.
-
SynonymsICodonolactone | 8β-Hydroxyasterolide
-
PathwayOthers
-
TargetOther Targets
-
RecptorApoptosis inducer
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number73030-71-4
-
Formula Weight248.32
-
Molecular FormulaC15H20O3
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 100 mg/mL; 402.71 mM
-
SMILESC=C1CCC[C@]2([C@H]1CC1=C(C)C(=O)O[C@]1(C2)O)C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Zhao H,et al. Neuroscience. 2015 Apr 2;290:485-91.
molnova catalog
related products
-
Digiferruginol
Digiferruginol has cytotoxic activity. Digiferruginol and hederagenin show weak effect on porcine respiratory and reproductive syndrome virus (PRRSV) with an IC50 value of 80.5 ± 16.9 uM(SI = 19.9) and 43.2 ± 7.4 uM (SI = 13.1), respectively.
-
Glutathione synthesi...
Glutathione synthesis-IN-1 (DC-1) is an inhibitor of glutathione synthesis.
-
BAY1217389
BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).
