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Atractylenolide III
CAS No. 73030-71-4
Atractylenolide III( ICodonolactone | 8β-Hydroxyasterolide )
Catalog No. M19046 CAS No. 73030-71-4
Atractylenolide III may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 53 | In Stock |
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| 2MG | 31 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 75 | In Stock |
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| 25MG | 123 | In Stock |
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| 50MG | 176 | In Stock |
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| 100MG | 263 | In Stock |
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| 200MG | 390 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAtractylenolide III
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NoteResearch use only, not for human use.
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Brief DescriptionAtractylenolide III may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury.
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DescriptionAtractylenolide III may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung carcinoma by inducing the release of cytochrome c, upregulating the expression of Bax and translocating apoptosis-inducing factor.
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In VitroWestern Blot Analysis Cell Line:A549 Concentration:1, 10, 100 μM Incubation Time:24 h, 48 h Result:Increased active form of caspase-9, caspase-3, and the cleavage of PARP at 48 h.Increased the expression of proapoptotic protein bax, and induced AIF translocation to the nucleus at 24 h.
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In VivoAnimal Model:70% ethanol-induced gastric ulcers in rats Dosage:5 and 10 mg/kg Administration:p.o.Result:Inhibited gastric ulcer formation and the necrotic erosion of gastric mucosa.Downregulated the MMP-2/9 expression by activating the TIMP-2 and TIMP-1 expressions.
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SynonymsICodonolactone | 8β-Hydroxyasterolide
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PathwayOthers
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TargetOther Targets
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RecptorApoptosis inducer
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number73030-71-4
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Formula Weight248.32
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Molecular FormulaC15H20O3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL; 402.71 mM
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SMILESC=C1CCC[C@]2([C@H]1CC1=C(C)C(=O)O[C@]1(C2)O)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhao H,et al. Neuroscience. 2015 Apr 2;290:485-91.
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