Linderalactone( Linderalactone )

Catalog No. M19045 CAS No. 728-61-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Linderalactone
Note

Research use only, not for human use.
Brief Description

Linderalactone showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, values of IC5 is 8.48 μg/mL.
Description

Linderalactone is an NSAID isolated from Lindera aggregata.
In Vitro

Cell Viability Assay Cell Line:Lung cancer A549 cells Concentration:0 μM, 1.6 μM, 3.2 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time:24 hours Result:Inhibited the growth of A549 cells concentration-dependently.Apoptosis Analysis Cell Line:Lung cancer A549 cells Concentration:7.5 μM, 15 μM, 30 μM Incubation Time:Result:Induced apoptosis in A549 cells in a dose-dependent manner. Cell Cycle Analysis Cell Line:Lung cancer A549 cells Concentration:7.5 μM, 15 μM, 30 μM Incubation Time:24 hours Result:Induced G2/M cell cycle arrest.Western Blot Analysis Cell Line:Lung cancer A549 cells Concentration:7.5 μM, 15 μM, 30 μM Incubation Time:Result:Inhibited the JAK/STAT pathway in A549 cells.
In Vivo

——
Synonyms

Linderalactone
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

728-61-0
Formula Weight

244.29
Molecular Formula

C15H16O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 33.33 mg/mL (136.44 mM)
SMILES

CC1=CCCC2=CC(C3=C(C1)OC=C3C)OC2=O
Chemical Name

(R,7Z,10E)-3,11-dimethyl-4,8,9,12-tetrahydro-6H-4,7-(metheno)furo[3,2-c][1]oxacycloundecin-6-one