Cart
sales@molnova.com
L-Chicoric Acid
CAS No. 70831-56-0
L-Chicoric Acid( Chicoric Acid, )
Catalog No. M19025 CAS No. 70831-56-0
Cichoric acid has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 59 | In Stock |
|
| 2MG | 33 | In Stock |
|
| 5MG | 53 | In Stock |
|
| 10MG | 85 | In Stock |
|
| 25MG | 141 | In Stock |
|
| 50MG | 204 | In Stock |
|
| 100MG | 303 | In Stock |
|
| 200MG | 451 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameL-Chicoric Acid
-
NoteResearch use only, not for human use.
-
Brief DescriptionCichoric acid has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy.
-
DescriptionChicoric Acid is a natural compound. To date, plants from at least 63 genera and species have been found to contain chicoric acid, and while the compound is used as a processing quality indicator, it may also have useful health benefits. Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid stimulates AMP kinase pathway in L6 myotubes and extends lifespan in Caenorhabditis elegans.
-
In VitroL-Chicoric Acid inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 μM. L-Chicoric Acid clearly affects viral entry at concentrations of 5 μM and higher. L-Chicoric Acid also inhibits integration as indicated both by an increased ratio of two LTR circle DNA to cDNA and an accompanying decrease in integrated provirus. The EC50 of L-Chicoric Acid against HIV is approximately 500 nM, a concentration that does not inhibit HIV entry in H9 cells.The ED50 of L-Chicoric Acid against HIVNL4-3 control virus is 400 nM, while HIVNL4-3 passaged in the presence of 8 μM L-Chicoric Acid is completely resistant to the compound.
-
In Vivo——
-
SynonymsChicoric Acid,
-
PathwayOthers
-
TargetOther Targets
-
RecptorOthers
-
Research AreaInfection
-
Indication——
Chemical Information
-
CAS Number70831-56-0
-
Formula Weight474.37
-
Molecular FormulaC22H18O12
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (210.81 mM)
-
SMILESC1=CC(=C(C=C1C=CC(=O)OC(C(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)C(=O)O)O)O
-
Chemical Name(2R,3R)-2,3-Bis[[(E)-3-(3,4-dihydroxyphenyl)acryloyl]oxy]succinic Acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog
related products
-
Lefamulin
Lefamulin is a semi-synthetic compound that inhibits the synthesis of bacterial protein, which is required for bacteria to grow.
-
Spiraeoside
Spiraeoside (Standard) is the analytical standard of Spiraeoside. This product is intended for research and analytical applications. Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities.
-
N-CBZ-Phe-Arg-AMC hy...
N-CBZ-Phe-Arg-AMC hydrochloride (N-CBZ-Phe-Arg-AMC hydrochloride (65147-22-0 Free base)) is a cysteine peptidase and serine protease substrate that can be used to assess cysteine peptidase and serine protease activity.
