Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - T863

T863

CAS No. 701232-20-4

T863( T863, T 863, T-863 )

Catalog No. M19018 CAS No. 701232-20-4

T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 41 In Stock
5MG 67 In Stock
10MG 97 In Stock
25MG 219 In Stock
50MG 365 In Stock
100MG 531 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    T863
  • Note
    Research use only, not for human use.
  • Brief Description
    T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.
  • Description
    T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. IC50 value: Target: DGAT1 T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.
  • In Vitro
    ——
  • In Vivo
    Animal Model:C57BL6 normal mice (8 weeks old) or diet-induced obese (DIO) mice (10 months old, fed a high fat diet for 8 months).Dosage:30 mg/kg (5 μL/g)Administration:Oral administration; once a day for days 1-7 and twice a day for days 8-14 Result:Significantly delayed fat absorption and resulted in lipid accumulation in the distal small intestine of mice, mimicking the effects of genetic ablation of DGAT1.
  • Synonyms
    T863, T 863, T-863
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DGAT1
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    701232-20-4
  • Formula Weight
    394.47
  • Molecular Formula
    C22H26N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 50 mg/mL; 126.75 mM
  • SMILES
    O=C(O)C[C@@H]1CC[C@H](CC1)c2ccc(cc2)C4=Nc3c(ncnc3N)OC4(C)C
  • Chemical Name
    trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cao J, et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 1,4-Dideoxy-1,4-epit...

    1,4-Dideoxy-1,4-epithio-D-ribitol is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and possesses a broad spectrum of antitumor activity.1,4-Dideoxy-1,4-epithio-D-ribitol induces apoptosis through inhibition of DNA synthesis.

  • Capecitabine

    Prodrug of 5-Fluorouracil (5-FU). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.

  • BCH001

    BCH001 is a specific small-molecule inhibitor of PAPD5.BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells.?

Sign In Join Free