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JNJ-1661010
CAS No. 681136-29-8
JNJ-1661010( JNJ-1661010 | JNJ 1661010 | JNJ1661010 )
Catalog No. M18990 CAS No. 681136-29-8
JNJ-1661010 is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 10MG | 28 | In Stock |
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| 25MG | 57 | In Stock |
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| 50MG | 89 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJNJ-1661010
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NoteResearch use only, not for human use.
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Brief DescriptionJNJ-1661010 is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.
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DescriptionJNJ-1661010 is a selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 12 nM). JNJ-1661010 is a brain penetrant and active in vivo.
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In Vitro——
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In VivoJNJ-1661010 (Takeda-25; i.p.; 50 mg/kg) diminishes thermal hyperalgesia in the inflammatory rat carrageenan paw model. JNJ-1661010 (i.p.; 10 mg/kg) has a T1/2 of 35 mins, a CL of 0.032 mL/min/kg, and a Cmax of 1.58 μM for rats.
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SynonymsJNJ-1661010 | JNJ 1661010 | JNJ1661010
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PathwayOthers
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TargetOther Targets
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RecptorFAAH (human)| FAAH (rat)
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number681136-29-8
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Formula Weight365.45
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Molecular FormulaC19H19N5OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (273.64 mM)
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SMILESO=C(Nc1ccccc1)N1CCN(CC1)c1nc(ns1)c1ccccc1
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Chemical Name1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Karbarz MJ, et al. Anesth Analg, 2009, 108(1), 316-329.
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