AG1024

Research use only, not for human use.

AG-1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).

AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation.

AG1024 (Tyrphostin AG 1024; 2-10 μM; 1-5 days) shows a dose-dependent inhibition of cell proliferation. AG1024 (1-5 μM; 1-3 days) induces UT7-9 and Baf3-p210 cells apoptosis. AG1024 (2 μM; 6, 12 hours) downregulates phospho-Akt, Bcr-Abl and upregulates DNA-PKcs. Cell Proliferation Assay Cell Line:UT7-9 and Baf3-p210 cells Concentration:2, 5, 10 μM Incubation Time:1, 3, 5 days Result:Showed a dose-dependent inhibition of cell proliferation.Apoptosis Analysis Cell Line:UT7-9 and Baf3-p210 cells Concentration:1, 3, 5 μM Incubation Time:1, 2, 3 days Result:Induced apoptosis.Western Blot Analysis Cell Line:UT7-9 and Ba/F3-p210 cells Concentration:2 μM Incubation Time:6, 12 hours Result:Downregulated phospho-Akt, Bcr-Abl and upregulated DNA-PKcs.

AG1024 (Tyrphostin AG 1024; 30 μg; i.p.; per day; for 2 weeks) significantly delays the tumour growth. Animal Model:Female nude mice (6-8 weeks old)Dosage:30 μg Administration:IP; per day; for 2 weeks Result:Significantly delayed the tumour growth.

AG1024 | AG-1024 | AG 1024. Tyrphostin

Others

Other Targets

IGF-1R| Insulin Receptor

Cancer

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65678-07-1

305.17

C14H13BrN2O

>98% (HPLC)

DMSO : ≥ 50 mg/mL; 163.84 mM

CC(C)(C)c1c(c(cc(c1)C=C(C#N)C#N)Br)O

2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile

(-20℃)

With Ice Pack

≥ 2 years