Chalcone

Research use only, not for human use.

trans-Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.

trans-Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.

trans-Chalcone competitively inhibits porcine pancreatic α-amylase with a Ki of 48 μM. trans-Chalcone (30.23-98.03 μM; 24 hours) induces cell cycle arrest and apoptosis in MCF-7 cells. trans-Chalcone (20-80 μM; 24, 48 hours) reduces the expression of the apoptosis-related protein Bcl-2. trans-Chalcone (58.25 μM; 6, 24 hours) has greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours. trans-Chalcone (24 hours) inhibits MCF-7 cell viability (IC20=30.23 μM; IC50=58.25 μM; IC80=98.03 μM). trans-Chalcone (48 h) has IC50s of 41.53 μM and 48.41 μM for MCF-7 and 3T3 cell lines, respectively. trans-Chalcone exhibits a pronounced cytotoxicity activity. Apoptosis Analysis Cell Line:MCF-7 cell Concentration:30.23, 58.25, 98.03 μM Incubation Time:24 hours Result:Induced apoptosis of the breast cancer cell line. Cell Cycle Analysis Cell Line:MCF-7 cell Concentration:30.23, 58.25, 98.03 μM Incubation Time:24 hours Result:Caused cell cycle arrest in G1.Western Blot Analysis Cell Line:MCF-7 cell Concentration:20, 40, 80 μM Incubation Time:24, 48 hours Result:Reduced the expression of the apoptosis-related protein Bcl-2 and induced the expression of the CIDEA gene. There was marked degradation of cyclin D1 at 48 h.RT-PCR Cell Line:MCF-7 cell Concentration:58.25 μM Incubation Time:6, 24 hours Result:Had greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours.

——

——

Apoptosis

p53

Others

——

——

614-47-1

208.26

C15H12O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (480.17 mM)

c1ccc(cc1)/C=C/C(=O)c1ccccc1

——

(-20℃)

With Ice Pack

≥ 2 years