Schisandrin C

Research use only, not for human use.

Schisandrin C is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.

Schizandrin C is a compound that exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia.(In Vitro):Schisandrin C (25-100 μM; 48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). It also activates caspase-3 and -9 in U937 cells.Schisandrin C (25-100 μM; 48 hours) induces apoptosis in a dose-dependent manner. And the fragmentation of genomic DNA is also increased in U937 cells.Schisandrin C (25-100 μM; 72 hours) induces G1 arrest, it down-regulates cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, and also exhibits inhibition of pRB, and up-regulation of the Cdk inhibitor p21(WAF1/CIP1).(In Vivo):Schisandrin C (lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days) reduces Aβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously.

Schisandrin C (25-100 μM; 48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). It also activates caspase-3 and -9 in U937 cells.Schisandrin C (25-100 μM; 48 hours) induces apoptosis in a dose-dependent manner. And the fragmentation of genomic DNA is also increased in U937 cells.Schisandrin C (25-100 μM; 72 hours) induces G1 arrest, it down-regulates cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, and also exhibitsinhibition of pRB, and up-regulation of the Cdk inhibitor p21(WAF1/CIP1). Western Blot Analysis Cell Line:U937 cells Concentration:25 μM,50 μM,100 μM Incubation Time:48 hours Result:Decreased the expression of apoptosis related proteins.Apoptosis Analysis Cell Line:U937 cells Concentration:25 μM,50 μM,100 μM Incubation Time:48 hours Result:Induced cell apoptosis. Cell Cycle Analysis Cell Line:U937 cells Concentration:25 μM,50 μM,100 μM Incubation Time:48 hoursResult:Induced growth inhibition and G1 arrest of U937 cells.

Schisandrin C (lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days) reducesAβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously. Animal Model:Aβ1-42-induced Alzheimer’s disease mice Dosage:15-150 μg/kg Administration:Lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days Result:Exhibited potent neuroprotective effects linking to anti-ChEtotal activities and anti-oxidative mechanisms in Aβ1-42-induced amnestic mice.

Schizandrin C | Schizandrin-C

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Other Targets

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Cancer

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61301-33-5

384.42

C22H24O6

>98% (HPLC)

In Vitro:?DMSO : 8.33 mg/mL (21.67 mM)

C[C@H]1Cc4cc5OCOc5c(OC)c4c2c(OC)c3OCOc3cc2C[C@H]1C

A name could not be generated for this structure.

(-20℃)

With Ice Pack

≥ 2 years