Decursin

Research use only, not for human use.

Decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug.

Decursin is a phytochemical originally isolated from A. gigas with diverse biological activities. It reduces the growth of B16/F10 murine melanoma cells, via induction of apoptosis and increased caspase-3 activity.

Cell Viability Assay Cell Line:DU145 cells Concentration:0, 25, 50, 100 μM Incubation Time:24, 28, 72, 96 h Result:Showed a dose- and time- dependent inhibition cell growth with 22% to 51%, 21%to 68%, 9% to 72%, 42% to 90% growth inhibition after 24, 48, 72, and 96 hours oftreatment, respectively. And caused 15%-45% cell death.Cell Cycle Analysis Cell Line:DU145 cells Concentration:0, 25, 50, 100 μM Incubation Time:12-96 h Result:Caused 52%, 65%, and 78% DU145 cells in G1phase.Western Blot Analysis Cell Line:DU145 cells Concentration:0, 25, 50, 100 μM Incubation Time:24, 48 h Result:Did not show any any alteration inprotein levels of CDK2, CDK4, CDK6, cyclin D1, and cyclin E, but dose-dependent decreased in the expression of these proteins except cyclin E at 48 h.

Animal Model:C57BL/6J mice (LLC cells)Dosage:4 mg/kg Administration:S.c.; daily for 4 weeks Result:Delayed tumor formation and dramatically decreased tumor growth by inhibition of angiogenesis through VEGFR-2 signaling pathway.Animal Model:Eight-week-old adult C57BL/6J male and female miceDosage:50 mg/kg Administration:Intrathecal injection; three times at 2-day intervals, for 6 days Result:Demonstrated the analgesic ability in the in vivo model of paclitaxel-induced peripheral neuropathy.

Decursin

Others

Other Targets

PKCα

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5928-25-6

328.36

C19H20O5

>98% (HPLC)

DMSO : 125 mg/mL 380.68 mM;

CC(=CC(=O)OC1CC2=C(C=C3C(=C2)C=CC(=O)O3)OC1(C)C)C

3-methyl-2-butenoic acid, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester

(-20℃)

With Ice Pack

≥ 2 years