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Toosendanin
CAS No. 58812-37-6
Toosendanin( —— )
Catalog No. M18857 CAS No. 58812-37-6
Toosendanin has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-6 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
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| 5MG | 38 | In Stock |
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| 10MG | 49 | In Stock |
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| 25MG | 72 | In Stock |
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| 50MG | 91 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameToosendanin
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NoteResearch use only, not for human use.
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Brief DescriptionToosendanin has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-6 cells.
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DescriptionToosendanin possesses hepatotoxicity. Toosendanin has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-6 cells. Toosendanin is an effective insecticide for Ae.
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In Vitro——
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In VivoToosendanin (0.5 and 1 mg/kg, Intraperitoneal injection daily for 7 days) alleviates DSS-induced experimental colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling, and may provide a novel Chinese patent medicine for the treatment of murine colitis. Animal Model:Forty-eight male C57BL/6 mice weighing 20-22 g.Dosage:0.5 and 1 mg/kg.Administration:Intraperitoneal injection daily for 7 days.Result:Protected against DSS-induced colitis in mice.Inhibited the expression of proinflammatory cytokines in DSS-induced UC and improved oxidative stress.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number58812-37-6
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Formula Weight574.62
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Molecular FormulaC30H38O11
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (174.03 mM)
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SMILESCC(=O)OC1CC(C23COC(C1(C2CC(C4(C3C(=O)C(C5(C46C(O6)CC5C7=COC=C7)C)OC(=O)C)C)O)C)O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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alpha-Tocopherolquin...
During hypoxia in rats, levels of α-tocopherylquinon have been found to rise. It is reported to downregulate the respiratory activity of mitochondria.
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PACAP (1-38), human,...
PACAP (1-38), a novel neuropeptide isolated from the bovine hypothalamus is more active than vasoactive intestinal peptide (VIP) in stimulating adenylate cyclase (EC50=7 nM). PACAP 1-38 (10-9 M) increased substance P (SP), gastrin releasing peptide (GRP), and VIP release. PACAP 1-38 (10-8 M) inhibited gastrin secretion and stimulated somatostatin secretion and motility dose-dependently.
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7-O -Methylaloesinol
7-O-Methylaloesinol is a chromone derivative. 7-O-Methylaloesinol shows significant inhibitory effects against TNFα-induced NF-κB transcriptional activity with an IC50 value of 29.07 μM.
