Licochalcone B( Licochalcone B | Licochalcone-B )

Catalog No. M18855 CAS No. 58749-23-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Licochalcone B
Note

Research use only, not for human use.
Brief Description

Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model.
Description

Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. LCB and Licochalcone D(LCD) significantly reduced the LPS-induced production of NO, TNFalpha and MCP-1. A novel LCB derivative compound: (E)-3-(3, 4-dihydroxy-2-methoxyphenyl)-1-(2, 4-dihydroxyphenyl)prop-2-en-1-one inhibits inflammatory reactions in macrophages and protects mice from endotoxin shock.
In Vitro

Western Blot Analysis Cell Line:RAW264.7 cells Concentration:10 μM Incubation Time:1 h Result:Inhibited the phosphorylation of NF-κB at serine 276 but not at serine 536.
In Vivo

Animal Model:Mice induced by CCl4 Dosage:1, 5, 25 mg/kg Administration:Oral gavage.Result:Elevated the levels of SOD and GSH, and reduced the GSSG levels.
Synonyms

Licochalcone B | Licochalcone-B
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

CAS Number

58749-23-8
Formula Weight

286.28
Molecular Formula

C16H14O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 83.33 mg/mL (291.08 mM)
SMILES

COC1=C(C=CC(=C1O)O)C=CC(=O)C2=CC=C(C=C2)O
Chemical Name

(E)-1-(3,4-dihydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one