Platycodin D

Research use only, not for human use.

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA). Platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases, they can increase mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization.

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Animal Model:Genetically obese db/db mice Dosage:5 mg/kg Administration:Oral administration; 5 mg/kg, 5 times per week for 5 weeks Result:Significantly decreased body weight gain without affecting food intake of mice. Decreased the liver tissue weight and increased the weight of brown adipose tissue (BAT).

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Endocrinology/Hormones

AChR

PGE2

Others-Field

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58479-68-8

1225.34

C57H92O28

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (40.81 mM)

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(-20℃)

With Ice Pack

≥ 2 years