Hypericin( SGX301 | SGX-301 | NSC 622946 | hypericin )

Catalog No. M18782 CAS No. 548-04-9

Hypericin inhibits RANKL-mediated osteoclastogenesis via affecting ERK signalling in vitro and suppresses wear particle-induced osteolysis in vivo.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	136	In Stock
5MG	123	In Stock
10MG	182	In Stock
25MG	360	In Stock
50MG	520	In Stock
100MG	728	In Stock
200MG	Get Quote	In Stock
500MG	1479	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Hypericin
Note

Research use only, not for human use.
Brief Description

Hypericin inhibits RANKL-mediated osteoclastogenesis via affecting ERK signalling in vitro and suppresses wear particle-induced osteolysis in vivo.
Description

Hypericin, also known as SGX301, is a novel, first-in-class photodynamic therapy using a potent photosensitizer, synthetic hypericin, that is topically applied and activated by safe visible fluorescent light. This treatment avoids the risk of secondary malignancies (including melanoma) inherent with the frequently employed DNA-damaging chemotherapeutic drugs and other photodynamic therapies that are dependent on ultraviolet A (UVA) light exposure.
In Vitro

Cell Viability Assay Cell Line:Fibroblasts (Fb), melanocytes (Mc), and keratinocytes (Kc)Concentration:0.25 μM; 0.5 μM; 1 μM; 2 μM; 3 μM; 4 μM Incubation Time:24 hours Result:Showed the LD50 for Fb and Mc at 1.75 μM and 3.5 μM, respectively, and for Kc at a greater dose than 4 μM.Apoptosis Analysis Cell Line:Fibroblasts (Fb), melanocytes (Mc), and keratinocytes (Kc)Concentration:3 μM Incubation Time:24 hours Result:Showed a significant (p<0.001) early apoptotic Fb population (64%), and a smaller, significant (p<0.05) early apoptotic Mc population (20%).
In Vivo

Animal Model:18-20 week-old female BALB/c mice injected withCT26 carcinomas Dosage:10 mg/kg Administration:Intravenous injection; 10 mg/kg; once Result:Showed a four times delayed tumor growth compared to the control groups.
Synonyms

SGX301 | SGX-301 | NSC 622946 | hypericin
Pathway

Microbiology/Virology
Target

Antibiotic
Recptor

antibacterial|antiviral
Research Area

Others-Field
Indication

——

Chemical Information

CAS Number

548-04-9
Formula Weight

504.45
Molecular Formula

C30H16O8
Purity

>98% (HPLC)
Solubility

DMSO : 6.2 mg/mL 12.29 mM
SMILES

CC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O
Chemical Name

1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro(1,10,9,8-opqra)perylene-7,14-dione