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Myristic acid

CAS No. 544-63-8

Myristic acid( —— )

Catalog No. M18773 CAS No. 544-63-8

Myristic Acid, a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 41 In Stock
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1G 44 In Stock
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Biological Information

  • Product Name
    Myristic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Myristic Acid, a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases.
  • Description
    Myristic Acid, a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases. This compound has the ability to acylate proteins by covalently binding to the N-terminal glycine residues, in a process called N-terminal myristoylation. Myristoylation of substrate proteins by this fatty acid has the potential to activate and mediate many physiological pathways. Furthermore, saturated fatty acids have been reported to be essential for biological activities of lipopolysaccharides and have demonstrated the ability to induce expression of COX-2 and NFκB (nuclear factor κB) activation.
  • In Vitro
    Western Blot Analysis Cell Line:MAC-T Concentration:100, 150, 200 μM Incubation Time:24 h Result:Increased the level of protein ubiquitination.Cell Viability Assay Cell Line:J774A.1 macrophages Concentration:12.5, 25, 50, 100,200 μg/mL Incubation Time:24 h Result:Showed non-cytotoxic effects in LPS-stimulated J774A.1 macrophages at 25 μg/mL.
  • In Vivo
    Animal Model:TPA-induced ear edema in miceDosage:12.5, 25, 50, 100 mg/kg Administration:p.o.Result:Decreased ear edema inflammation in the acute and chronic TPA assays with IC50 values of 62 and 77 mg/kg, respectively in a dose-dependent manner.Attenuated the acetic acid-induced abdominal contortions with ED50 values of 32 mg/kg.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    544-63-8
  • Formula Weight
    228.38
  • Molecular Formula
    C14H28O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 250 mg/mL; 1094.71 mM
  • SMILES
    O=C(O)CCCCCCCCCCCCC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lee JY,etal.Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem. 2001 May 18;276(20):16683-9.
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