Polyphyllin I

Research use only, not for human use.

Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels.

Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.

Cell Proliferation Assay Cell Line:A549, H460, and SK-MES-1 cells Concentration:24, 48, 72 hours Incubation Time:24, 48, 72 hours Result:Markedly reduced proliferation capacity in vitro and in a concentration-dependent manner.

Animal Model:BALB/c nude mice (5 weeks old) were s.c. inoculated with A549 cells Dosage:1.5 mg/kg Administration:I.p. twice daily from day 2 to day 11 Result:The tumor growth rate was much lower than that in cisplatin group and PBS group.

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Apoptosis

NF-κB

Others

Others-Field

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50773-41-6

855.03

C44H70O16

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (116.96 mM)

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(-20℃)

With Ice Pack

≥ 2 years