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Phloracetophenone
CAS No. 480-66-0
Phloracetophenone( —— )
Catalog No. M18613 CAS No. 480-66-0
2', 4', 6'-Trihydroxyacetophenone has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePhloracetophenone
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NoteResearch use only, not for human use.
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Brief Description2', 4', 6'-Trihydroxyacetophenone has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.
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Description2', 4', 6'-Trihydroxyacetophenone has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.
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In VitroPhloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level.Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver.
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In VivoPhloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetMMP
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RecptorOthers
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number480-66-0
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Formula Weight168.15
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Molecular FormulaC8H8O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (148.68 mM)
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SMILESCC(=O)c1c(cc(cc1O)O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lai YH, et al. Rapid Commun Mass Spectrom. 2014 Aug 15;28(15):1716-22.
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