Linarin( Linarin )

Catalog No. M18609 CAS No. 480-36-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Linarin
Note

Research use only, not for human use.
Brief Description

Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase.
Description

Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediated apoptotic pathways. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin.
In Vitro

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In Vivo

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Synonyms

Linarin
Pathway

Others
Target

Other Targets
Recptor

TNF-α inhibitor
Research Area

Others-Field
Indication

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CAS Number

480-36-4
Formula Weight

592.55
Molecular Formula

C28H32O14
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (421.91 mM)
SMILES

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)OC)O)O)O)O)O)O)O
Chemical Name

7-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one