alpha-Boswellic acid

Research use only, not for human use.

Boswellic acids are a series of pentacyclic triterpene molecules that are produced by plants in the genus Boswellia.

Boswellic acid promotes induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway.

RT-PCR Cell Line:HaCaT Concentration:1, 3, 10 μM Incubation Time:20 min Result:Decreased IL-1β, IL-6, IL-8, MDC, and TARC mRNA expression.Increased the mRNA expression of involucrin, filaggrin, and loricrin in TNF-α/IFN-γ-induced cells.Western Blot Analysis Cell Line:HaCaT Concentration:1, 3, 10 μM Incubation Time:20 min Result:Inhibited ERK, p38, and JNK protein phosphorylation.Reduced the phosphorylated NF-κB protein levels.

Animal Model:2,4-Dinitrochlorobenzene-Induced Atopic-like Dermatitis in BALB/c MiceDosage:3 or 10 mg/kg Administration:i.p.Result:Reduced the severity of the AD-like symptoms.Attenuated the increase in ear thickness and decreased cutaneous TEWL in DNCB-treated mice.Animal Model:Ethanol-induced gastric injury in rats Dosage:200 mg/kg Administration:i.g.Result:Reduced injuries associated with the administration of ethanol, gastric juice acidity and the formation of MDA and increased CAT activity and SOD activity and the level of NO and PGE-2 in a dose-depended manner.Increased the expression of both Nrf2 and HO-1.

Boswellic acid

Others

Other Targets

Others

Others-Field

——

471-66-9

456.7

C30H48O3

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (54.74 mM)

CC1(C)CC[C@]2(C)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@@H](O)[C@@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2C1

(3R,4R,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-3-hydroxy-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years