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Lasmiditan

CAS No. 439239-90-4

Lasmiditan( COL-144 | LY573144 )

Catalog No. M18554 CAS No. 439239-90-4

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study.

Purity : >98% (HPLC)

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2MG	92	In Stock
5MG	138	In Stock
10MG	239	In Stock
25MG	525	In Stock
50MG	957	In Stock
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Biological Information

Product Name

Lasmiditan
Note

Research use only, not for human use.
Brief Description

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study.
Description

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.
In Vitro

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In Vivo

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Synonyms

COL-144 | LY573144
Pathway

Others
Target

Other Targets
Recptor

5-HT1F
Research Area

Neurological Disease
Indication

——

Chemical Information

CAS Number

439239-90-4
Formula Weight

377.14
Molecular Formula

C19H18F3N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

CN1CCC(CC1)C(=O)c1nc(ccc1)NC(=O)c1c(cc(cc1F)F)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Nelson DL, et al. Cephalalgia. 2010 Oct;30(10):1159-69.

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