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Lasmiditan
CAS No. 439239-90-4
Lasmiditan( COL-144 | LY573144 )
Catalog No. M18554 CAS No. 439239-90-4
Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 92 | In Stock |
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| 5MG | 138 | In Stock |
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| 10MG | 239 | In Stock |
|
| 25MG | 525 | In Stock |
|
| 50MG | 957 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLasmiditan
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NoteResearch use only, not for human use.
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Brief DescriptionLasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study.
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DescriptionLasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.
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In Vitro——
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In Vivo——
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SynonymsCOL-144 | LY573144
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PathwayOthers
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TargetOther Targets
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Recptor5-HT1F
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number439239-90-4
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Formula Weight377.14
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Molecular FormulaC19H18F3N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1CCC(CC1)C(=O)c1nc(ccc1)NC(=O)c1c(cc(cc1F)F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nelson DL, et al. Cephalalgia. 2010 Oct;30(10):1159-69.
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