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Timosaponin AIII

CAS No. 41059-79-4

Timosaponin AIII( Timosaponin AIII )

Catalog No. M18529 CAS No. 41059-79-4

Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 92 In Stock
5MG 61 In Stock
10MG 107 In Stock
25MG 227 In Stock
50MG 319 In Stock
100MG 479 In Stock
200MG 695 In Stock
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Biological Information

  • Product Name
    Timosaponin AIII
  • Note
    Research use only, not for human use.
  • Brief Description
    Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM).
  • Description
    Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
  • In Vitro
    Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM. Timosaponin AIII is identified as a major selective cytotoxic activity in BN108, and its selective cytotoxic activity involves inhibition of mTOR, induction of ER stress and protective autophagy.
  • In Vivo
    Of the tested steroidal saponins, Timosaponin AIII (TA3) most potently improves memory deficits. Timosaponin AIII increases the scopolamine-induced reduction in step-through latency by 17% (10 mg/kg), 28% (20 mg/kg), and 43% (40 mg/kg). During the acquisition trial, no differences in latent time are observed. Timosaponin AIII (20, 40 mg/kg, p.o.) potently inhibits this reduction of acetylcholine in scopolamine-treated mouse brain. The inhibitory effect of Timosaponin AIII is comparable to that of tacrine, which is used as a positive control.
  • Synonyms
    Timosaponin AIII
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    mTORC1
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    41059-79-4
  • Formula Weight
    740.92
  • Molecular Formula
    C39H64O13
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (168.71 mM)
  • SMILES
    [C@]12([C@@H]3[C@H](C[C@H]1[C@H]1[C@H](CC2)[C@@]2([C@H](CC1)C[C@H](CC2)O[C@H]1[C@H](O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)[C@H]([C@H]([C@H](O1)CO)O)O)C)O[C@@]1([C@H]3C)CC[C@H](CO1)C)C
  • Chemical Name
    [(25S)-5?-Spirostan-3?-yl]2-O-(?-D-glucopyranosyl)-?-D-galactopyranoside

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wu ZT, et al. Acta Pharmacol Sin. 2014 Sep;35(9):1188-98.
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