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Methyl 4-hydroxycinnamate
CAS No. 3943-97-3
Methyl 4-hydroxycinnamate( —— )
Catalog No. M18519 CAS No. 3943-97-3
Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMethyl 4-hydroxycinnamate
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NoteResearch use only, not for human use.
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Brief DescriptionMethyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia.
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DescriptionMethyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens.
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In VitroWestern Blot Analysis Cell Line:Phorbol 12-myristate 13-acetate (HY-18739) (10 nM, 1 h)-stimulated A549 cells Concentration:0-100 μM Incubation Time:1 h Result:Inhibited PMA-stimulated phosphorylation of IκBα and p65,as well as c-Jun/c-Fos phosphorylation and c-Jun/c-Fos nuclear translocation.
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In VivoAnimal Model:Ovalbumins (HY-W250978)-induced mice with allergic asthma Dosage:5 mg/kg Administration:p.o.Result:Inhibited the secretion of Th2 cytokines, MCP-1, and IgE.Inhibited eosinophil/macrophage influx.Inhibited immune cell influx and mucus secretion.
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Synonyms——
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PathwayGPCR/G Protein
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TargetProstaglandin Receptor
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number3943-97-3
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Formula Weight178.18
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Molecular FormulaC10H10O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (561.23 mM)
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SMILESCOC(=O)/C=C/c1ccc(cc1)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tan EM, et al. J Phys Chem B. 2013 May 2;117(17):4798-805.
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