Madecassoside( Asiaticoside A )

Catalog No. M18455 CAS No. 34540-22-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Madecassoside
Note

Research use only, not for human use.
Brief Description

Madecassoside is a pentacyclic triterpene extracted from Centella asitica (L.) with anti-inflammatory, anti-oxidative and anti-aging activities.
Description

Madecassoside is a pentacyclic triterpene extracted from Centella asitica (L.) with anti-inflammatory, anti-oxidative and anti-aging activities.
In Vitro

Cell Viability Assay Cell Line:HUVECs Concentration:10, 30, 100 μmol/L Incubation Time:12 h Result:Increased cell viability to 68.9% and 78.3%, with concentration of 30 and 100 μmol/L, respectively.Western Blot Analysis Cell Line:HUVECs Concentration:10, 30, 100 μmol/L Incubation Time:12 h Result:Inhibited phosphorylation in p38 MAPK.
In Vivo

Animal Model:Focal cerebral ischemia reperfusion injury in Sprague Dawley rats Dosage:6, 12, 24 mg/kg Administration:Intravenous injection Result:Reduced neurological deficit, infarct area, brain damage and neuronal apoptosis.Animal Model:Lipopolysaccharide-induced neurotoxicity in Sprague-Dawley rats Dosage:30-120 mg/kg for 14 days Administration:Intraperitoneal injection Result:Reduced LPS-induced cognitive impairment and imflammatory cytokine, promoted Nrf2 pathway at concentration of 120 mg/kg.
Synonyms

Asiaticoside A
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

34540-22-2
Formula Weight

975.12
Molecular Formula

C48H78O20
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 9.8 mg/mL; 10.05 mM
SMILES

[C@@H]1([C@@H](CC[C@@]2(CC[C@@]3([C@@]4(C[C@H]([C@H]5[C@]([C@H]([C@@H](C[C@@]5([C@H]4CC=C3[C@H]12)C)O)O)(C)CO)O)C)C)C(=O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O)O)O)O)O)C)C
Chemical Name

——

1. Lin X, et al. Pharmacol Biochem Behav. 2014 Sep;124:434-42.

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