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TRAM-34

CAS No. 289905-88-0

TRAM-34( TRAM-34 | TRAM34 | TRAM 34 )

Catalog No. M18371 CAS No. 289905-88-0

TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 46 In Stock
10MG 41 In Stock
25MG 77 In Stock
50MG 138 In Stock
100MG 181 In Stock
200MG 235 In Stock
500MG 395 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    TRAM-34
  • Note
    Research use only, not for human use.
  • Brief Description
    TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450.
  • Description
    TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli, and does not block cytochrome P450.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TRAM-34 | TRAM34 | TRAM 34
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    IKCa1 (KCa3.1)
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    289905-88-0
  • Formula Weight
    344.84
  • Molecular Formula
    C22H17ClN2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 3.5 mg/mL; 10.15 mM
  • SMILES
    n1(nccc1)C(c1ccccc1)(c1ccccc1)c1c(cccc1)Cl
  • Chemical Name
    1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wulff H, et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8151-6.
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