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alpha-Asarone
CAS No. 2883-98-9
alpha-Asarone( α-Asarone | trans-Asarone )
Catalog No. M18369 CAS No. 2883-98-9
Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | 27 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Namealpha-Asarone
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NoteResearch use only, not for human use.
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Brief DescriptionAlpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
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DescriptionAlpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.(In Vitro):The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells.(In Vivo):The present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.
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In VitroThe results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells.
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In VivoThe present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.
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Synonymsα-Asarone | trans-Asarone
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PathwayOthers
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TargetOther Targets
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RecptorHMGCR| CYP2D6| CYP3A4
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number2883-98-9
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Formula Weight208.3
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Molecular FormulaC12H16O3
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL 480.19 mM; H2O : < 0.1 mg/mL
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SMILESC/C=C/c1cc(c(cc1OC)OC)OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Limón, L, et al. Neuroscience Letters 453(2), 2009, 98-103.
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