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(+)-Catechin Hydrate
CAS No. 225937-10-0
(+)-Catechin Hydrate( (+)-Catechin Hydrate )
Catalog No. M18265 CAS No. 225937-10-0
(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological systems.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
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| 50MG | 28 | In Stock |
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| 100MG | 37 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 83 | In Stock |
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| 1G | 120 | In Stock |
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Biological Information
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Product Name(+)-Catechin Hydrate
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NoteResearch use only, not for human use.
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Brief Description(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological systems.
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Description(+)-Catechin Hydrate is an antioxidant, as a plant secondary metabolite, inhibiting intestinal tumor formation and the oxidation of low density lipoprotein.
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In Vitro(+)-Catechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC50 of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis. The expression levels of Caspase-3, -8, and -9 and p53 in MCF-7 cells treated with 150 μg/mL (+)-Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells.
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In VivoAnimals treated with (+)-Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively).
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Synonyms(+)-Catechin Hydrate
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PathwayOthers
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TargetOther Targets
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RecptorAntioxidant
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number225937-10-0
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Formula Weight308.28
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Molecular FormulaC15H16O7
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Purity>98% (HPLC)
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SolubilityDMSO : 150 mg/mL
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SMILESC1[C@@H]([C@H](Oc2cc(cc(c12)O)O)c1cc(c(cc1)O)O)O.O
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Chemical Name(2R,3S)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol hydrate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Celosin J
Celosin J is a natural compound that can be isolated from Celosia argentea seeds.
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Obatoclax B
Obatoclax (GX15-070), a pan-BCL-2 family proteins inhibitor and BH3 mimetic, exhibits a binding affinity (K_i) of 220 nM for BCL-2. It promotes autophagy-dependent cell death and cyclin D1 degradation via the proteasome.
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Gly-Gly-Gly|H-Gly-Gl...
H-Gly-Gly-Gly-OH (Standard) is the analytical standard of H-Gly-Gly-Gly-OH. This product is intended for research and analytical applications. H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.
