Hydrocortisone 21-hemisuccinate

Research use only, not for human use.

Hydrocortisone 21-hemisuccinate is a corticosteroid used as an analytical and chromatography reagent.

Hydrocortisone hemisuccinate anhydrous is an anti-inflammatory agent.(In Vitro):Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.(In Vivo):Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice.

Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.

Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice. Animal Model:Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis Dosage:30 mg/kg Administration:P.o. twice daily for 5 days Result:Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.Increased the body weight.

Hydrocortisone hemisuccinate anhydrous

Others

Other Targets

Others

——

——

2203-97-6

462.53

C25H34O8

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (540.51 mM)

[H][C@@]12CC[C@](O)(C(=O)COC(=O)CCC(O)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

4-(2-((8S,9R,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)-4-oxobutanoic acid

(-20℃)

With Ice Pack

≥ 2 years