7,8-Dihydroxy-4-methylcoumarin
CAS No. 2107-77-9
7,8-Dihydroxy-4-methylcoumarin( DHMC )
Catalog No. M18233 CAS No. 2107-77-9
4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name7,8-Dihydroxy-4-methylcoumarin
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NoteResearch use only, not for human use.
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Brief Description4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.
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DescriptionDHMC is a selective cytotoxic to leukemic cells over normal blood cells.
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In Vitro——
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In Vivo——
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SynonymsDHMC
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PathwayMetabolic Enzyme/Protease
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TargetMAO
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Recptor5-Lipoxygenase
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Research Area——
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Indication——
Chemical Information
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CAS Number2107-77-9
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Formula Weight192.17
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Molecular FormulaC10H8O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (433.63 mM)
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SMILESCC1=CC(=O)OC2=C1C=CC(=C2O)O
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Chemical Name7,8-dihydroxy-4-methylcoumarin
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CHBO4
CHBO4 is an hMAO-B inhibitor that is potent, reversible, competitive and selective.The IC50 value of CHBO4 against hMAO-B in the CHBO assay was 0.031 μM, and the Ki value was 0.010 ± 0.005 μM.CHBO4 reduces cellular damage by scavenging intracellular reactive oxygen species (ROS), and can be used to study Parkinson's disease (PD).
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Harmine
Banisterine monohydrate(Harmine), a tricyclic b-carboline alkaloid that was originally isolated from seeds of Peganum harmala, has been reported to possess anxiolytic, behavioral effects.
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Moclobemide
Moclobemide(Ro111163) is a reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder.
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