Panaxadiol

Research use only, not for human use.

Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.

Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.

Panaxadiol (1-10 μM, 12 h) inhibits PD-L1 expression in human colon cancer cells.Panaxadiol (1-10 μM, 12 h) inhibits the expression of PD-L1 by suppressing HIF-1α and STAT3 in HCT116 cells. Western Blot AnalysisCell Line:HCT116, SW620 and HT-29 colon cancer cells Concentration:1, 3, and 10 μM Incubation Time:12 hours Result:Decreased the expression of PD-L1 protein and mRNA in a dose-dependent manner.Western Blot Analysis Cell Line:HCT116 cells Concentration:1, 3, and 10 μM Incubation Time:12 hours Result:Inhibited hypoxia-induced nuclear accumulation of HIF-1α in a dose-dependent manner.Inhibited STAT3 phosphorylation at Tyr705 in a dose-dependent manner under both normoxic and hypoxic conditions.

Panaxadiol (oral gavage; 10 or 30 mg/kg; once every 3 days; 30 d) inhibits the growth of HCT116 cells in a xenograft model. Animal Model:BALB/c athymic nude mice injected with HCT116 cells Dosage:10 or 30 mg/kg Administration:Oral gavage; 10 or 30 mg/kg; once every 3 days; 30 days Result:Inhibited the protein levels of HIF-1α, p-STAT-3 (Tyr705), PD-L1 and VEGF in tumour tissues in a dose-dependent manner.

20(R)-Panaxadiol

Others

Other Targets

Others

Cancer

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19666-76-3

460.73

C30H52O3

>98% (HPLC)

Ethanol : 20 mg/mL 43.41 mM;

O[C@H]1[C@H]2[C@]([C@]3([C@@H]([C@@]4([C@@H](CC3)C([C@@H](O)CC4)(C)C)C)C1)C)(CC[C@@H]2[C@@]1(OC(CCC1)(C)C)C)C

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(-20℃)

With Ice Pack

≥ 2 years