LY310762( LY310762 | LY 310762 | LY-310762 )

Catalog No. M18182 CAS No. 192927-92-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LY310762
Note

Research use only, not for human use.
Brief Description

LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
Description

LY310762 is a 5-HT1D antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.
In Vitro

LY310762 (0.01-1 μM) shows potentiation of potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 value of 31 nM.LY310762 (10 μM) significantly but not completely blocks the extent of sumatriptan-induced decrease in EPSCs (excitatory postsynaptic potential).
In Vivo

LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo.LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model. Animal Model:Dunkin Hartley guinea pigs (female; 350-400 g, Harlan).Dosage:10 mg/kg Administration:Intraperitoneal injection; single Result:Produced a further significant enhancement in the 5-HT response to fluoxetine.Animal Model:Male Wistar rats (270-330 g; phenylephrine-infusion rats model).Dosage:1 mg/kg Administration:Intravenous injection; single Result:Completely abolished 5-HT vasodilator effects.
Synonyms

LY310762 | LY 310762 | LY-310762
Pathway

Others
Target

Antioxidant
Recptor

5-HT1D
Research Area

Neurological Disease
Indication

——

CAS Number

192927-92-7
Formula Weight

430.94
Molecular Formula

C24H27FN2O2·HCl
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 44 mg/mL; 102.10 mM
SMILES

Cl.CC1(C)C(=O)N(CCN2CCC(CC2)C(=O)c2ccc(F)cc2)c2ccccc12
Chemical Name

1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-dimethylindolin-2-one hydrochloride

1. Pullar IA, et al. Eur J Pharmacol, 2004, 493(1-3), 85-93.

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