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Gracillin

CAS No. 19083-00-2

Gracillin( Gracillin | NSC-698787 | NSC 698787 | NSC698787 )

Catalog No. M18168 CAS No. 19083-00-2

Gracillin can induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells, and has the potential to be developed as an antitumor agent.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 65 In Stock
2MG 29 In Stock
5MG 42 In Stock
10MG 67 In Stock
25MG 128 In Stock
50MG 197 In Stock
100MG 291 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    Gracillin
  • Note
    Research use only, not for human use.
  • Brief Description
    Gracillin can induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells, and has the potential to be developed as an antitumor agent.
  • Description
    Gracillin is a steroidal saponin that has been found in C. speciosus and has diverse biological activities. Gracillin induces apoptosis in HL60 human leukemic cell line via oxidative stress and cell cycle arrest of G1.
  • In Vitro
    Apoptosis Analysis Cell Line:A549 cells Concentration:0-4 μM Incubation Time:24 h Result:Induced morphological changes.Apoptosis rate: 6.56%-67.43%.
  • In Vivo
    ——
  • Synonyms
    Gracillin | NSC-698787 | NSC 698787 | NSC698787
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    cell cycle arrest
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    19083-00-2
  • Formula Weight
    885.05
  • Molecular Formula
    C45H72O17
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (112.99 mM)
  • SMILES
    [C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O[C@H]1[C@@H]([C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@@H]5O[C@@]6([C@H]([C@@H]5[C@]4(CC[C@@H]3[C@]2(CC1)C)C)C)CC[C@H](CO6)C)CO)O
  • Chemical Name
    (2S,3R,4S,5R,6R)-2-(((2R,3R,4S,5R,6R)-3-hydroxy-2-(hydroxymethyl)-6-(((4S,5'R,6aR,6bS,8aR,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)-5-(((2S,3R,4R,5R,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen CR,et al.Gracillin induces apoptosis in HL60 human leukemic cell line via oxidative stress and cell cycle arrest of G1.Pharmazie. 2015 Mar;70(3):199-204.
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