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C-DIM12
CAS No. 178946-89-9
C-DIM12( C-DIM12 | C-DIM 12 | C-DIM-12 )
Catalog No. M18138 CAS No. 178946-89-9
C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 36 | In Stock |
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| 25MG | 79 | In Stock |
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| 50MG | 124 | In Stock |
|
| 100MG | 198 | In Stock |
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| 200MG | 294 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameC-DIM12
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NoteResearch use only, not for human use.
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Brief DescriptionC-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA.
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DescriptionC-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons.
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In Vitro——
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In Vivo——
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SynonymsC-DIM12 | C-DIM 12 | C-DIM-12
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PathwayOthers
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TargetOther Targets
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RecptorNurr1 activator
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number178946-89-9
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Formula Weight356.85
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Molecular FormulaC23H17ClN2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL 280.23 mM; H2O : < 0.1 mg/mL
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SMILESClc1ccc(C(c2c[nH]c3c2cccc3)c2c[nH]c3c2cccc3)cc1
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Chemical Name1,1-bis(3-indolyl)-1-(p-chlorophenyl)methane
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hammond SL, Safe S, Tjalkens RB. Neurosci Lett. 2015 Oct 21;607:83-9.
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