4-hydroxyphenylacetic acid

Research use only, not for human use.

4-Hydroxybenzeneacetate acid is considered to be slightly soluble (in water) and acidic. 4-Hydroxybenzeneacetate acid can be synthesized from acetic acid.

4-Hydroxybenzeneacetate acid is considered to be slightly soluble (in water) and acidic. 4-Hydroxybenzeneacetate acid can be synthesized from acetic acid. It can be found throughout numerous foods such as Olives, Cocoa beans, Oats, and Mushrooms. 4-Hydroxybenzeneacetate acid can be found throughout all human tissues and in all biofluids. Within a cell, 4-Hydroxybenzeneacetate acid is primarily located in the cytoplasm and in the extracellular space.(In Vivo):4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1.

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4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1.

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Others

Other Targets

Others

Others-Field

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156-38-7

152.15

C8H8O3

>98% (HPLC)

DMSO : ≥ 100 mg/mL; 657.25 mM

OC(=O)Cc1ccc(cc1)O

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(-20℃)

With Ice Pack

≥ 2 years