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ID-8

CAS No. 147591-46-6

ID-8( ID-8 | ID 8 | ID8 )

Catalog No. M18041 CAS No. 147591-46-6

ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 42 In Stock
5MG 38 In Stock
10MG 53 In Stock
25MG 93 In Stock
50MG 152 In Stock
100MG 226 In Stock
200MG 334 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    ID-8
  • Note
    Research use only, not for human use.
  • Brief Description
    ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
  • Description
    ID-8 is a DYRK inhibitor. ID-8 could support Wnt-induced human embryonic stem cell proliferation and survival without differentiation. Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) is the target of the small molecule ID-8. Its role in human pluripotent cell renewal was confirmed by DYRK knockdown in human embryonic stem cells.
  • In Vitro
    ID-8 (0.1-10 μM) increases human embryonic stem cell (hESC) survival.ID-8 (10 μM) stimulates ESCs proliferation in serum-free media for more than 1 month.
  • In Vivo
    ——
  • Synonyms
    ID-8 | ID 8 | ID8
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    DYRK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    147591-46-6
  • Formula Weight
    298.29
  • Molecular Formula
    C16H14N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 47 mg/mL; 157.56 mM
  • SMILES
    COc1ccc(cc1)n1c(C)c(c2c1cc(O)cc2)[N+](=O)[O-]
  • Chemical Name
    1-(4-methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Miyabayashi T, et al. Biosci Biotechnol Biochem. 2008 , 72(5), 1242-1248.
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