LICOCHALCONEC( Licochalcone C | Licochalcone-C )

Catalog No. M18021 CAS No. 144506-14-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

LICOCHALCONEC
Note

Research use only, not for human use.
Brief Description

Licochalcone C has potent antioxidant properties and inhibition of bacterial growth and cellular respiration.
Description

Licochalcone C is an inhibitor of lipopolysaccharide-interferon-γ inflammation. It acts by improving antioxidant conditions and regulating inducible nitric oxide synthase expression. It acts as an inhibitor of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate.
In Vitro

Licochalcone C could inhibit α- glucosidase, with IC50s of <100 nM and 92.43 μM for α- glucosidase and PTP1B, respectively. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration?dependent manner. Licochalcone C treatment reduces the levels of the anti?apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells.
In Vivo

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Synonyms

Licochalcone C | Licochalcone-C
Pathway

Others
Target

Other Targets
Recptor

Antioxidant
Research Area

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Indication

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CAS Number

144506-14-9
Formula Weight

338.39
Molecular Formula

C21H22O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 33.33 mg/mL (98.49 mM)
SMILES

COc1c(\C=C\C(=O)c2ccc(O)cc2)ccc(O)c1CC=C(C)C
Chemical Name

(E)-3-[4-Hydroxy-2-methoxy-3-(3-methylbut-2-enyl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one

1. Zhou M, et al. Life Sciences, 2015, 132:27-33.

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