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GSK J1
CAS No. 1373422-53-7
GSK J1( GSKJ1 | GSKJ 1 | GSKJ-1 )
Catalog No. M17982 CAS No. 1373422-53-7
GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 64 | In Stock |
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| 5MG | 38 | In Stock |
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| 10MG | 60 | In Stock |
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| 25MG | 93 | In Stock |
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| 50MG | 174 | In Stock |
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| 100MG | 289 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK J1
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NoteResearch use only, not for human use.
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Brief DescriptionGSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively.
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DescriptionGSKJ1 is a selective and potent histone demethylase inhibitor (GSK-J1) that has significant activity (IC50 60 nM for human JmjD3) in vitro and in cells using an ester derivative (GSK-J4: 1 μM < IC50 < 10 μM; e.g. 9 μM in primary human macrophages). The pyridine regio-isomer GSK-J2 displays significantly less on-target activity (IC50 > 100 μM for human JmjD3) and thus can be used as control for target effects in vitro, and as ester derivative (GSK-J5) in cells. Recent data has shown that GSK-J1 also shows some activity (IC50 950 nM for Jarid1b, IC50 1.76 uM for Jarid1c) against H3K4me3/2/1 demethylases.
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In Vitro——
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In Vivo——
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SynonymsGSKJ1 | GSKJ 1 | GSKJ-1
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PathwayOthers
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TargetOther Targets
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RecptorJMJD3 (KDM6B)|UTX (KDM6A)
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number1373422-53-7
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Formula Weight389.45
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Molecular FormulaC22H23N5O2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 33 mg/mL; 84.73 mM
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SMILESOC(=O)CCNC1=CC(=NC(=N1)C1=CC=CC=N1)N1CCC2=C(CC1)C=CC=C2
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Chemical Name3-((2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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